以色列研究人員研發發現新抗體的新方法
文章來源:未知 文章作者:enread 發布時間:2020-02-12 07:25 字體: [ ]  進入論壇
(單詞翻譯:雙擊或拖選)
Israeli researchers have developed a novel method for screening and detecting new efficient antibiotics1, Ben Gurion University (BGU) in southern Israel said Tuesday.
 
以色列本古里安大學周二表示,該校研究人員發現一種篩選發現新型有效抗體的新方法。
 
The method, published in the journal Chemical Science, can help fight antibiotic-resistant bacteria.
 
According to the researchers, the new technology provides an efficient, fast and cost-effective way to identify novel antibiotics that inhibit2 the ribosome, which is the protein-producing machinery3 of all living cells.
 
Inhibition of ribosomal activity in bacterial4 cells, using antibiotics, results in depletion5 of essential proteins and finally in cell death.
 
However, the ribosome is a huge complex containing both RNA molecules6 and several proteins, so identifying drugs that will inhibit its activity is a challenging task.
 
The new method designs antibiotics that target a small RNA region in the ribosome, as focusing on this region allows quick and efficient screening and designing of drugs.
 
The new technology combines empirical screening of small molecular7 fragments that bind8 this RNA region using nuclear magnetic resonance9, with machine learning algorithms that enable the computational design of novel drugs based on the fragments.
 
According to the researchers, their workflow design is applicable not only to antibiotics targeting the ribosome RNA but also for other RNA targets, such as RNA viruses responsible for diseases such as hepatitis or HIV, as well as for other conditions such as cancer.


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1 antibiotics LzgzQT     
n.(用作復數)抗生素;(用作單數)抗生物質的研究;抗生素,抗菌素( antibiotic的名詞復數 )
參考例句:
  • the discovery of antibiotics in the 20th century 20世紀抗生素的發現
  • The doctor gave me a prescription for antibiotics. 醫生給我開了抗生素。
2 inhibit C7jxT     
vt.阻止,妨礙,抑制
參考例句:
  • Don't let ego and greed inhibit clear thinking and hard work.不要讓自我和貪婪妨礙清晰的思維和刻苦的工作。
  • They passed a law to inhibit people from parking in the street.他們通過一項法令以阻止人們在街上停車。
3 machinery CAdxb     
n.(總稱)機械,機器;機構
參考例句:
  • Has the machinery been put up ready for the broadcast?廣播器材安裝完畢了嗎?
  • Machinery ought to be well maintained all the time.機器應該隨時注意維護。
4 bacterial dy5z8q     
a.細菌的
參考例句:
  • Bacterial reproduction is accelerated in weightless space. 在失重的空間,細菌繁殖加快了。
  • Brain lesions can be caused by bacterial infections. 大腦損傷可能由細菌感染引起。
5 depletion qmcz2     
n.耗盡,枯竭
參考例句:
  • Increased consumption of water has led to rapid depletion of groundwater reserves.用水量的增加導致了地下水貯備迅速枯竭。
  • Farmers should rotate crops every season to prevent depletion of the soil.農夫每季應該要輪耕,以免耗盡土壤。
6 molecules 187c25e49d45ad10b2f266c1fa7a8d49     
分子( molecule的名詞復數 )
參考例句:
  • The structure of molecules can be seen under an electron microscope. 分子的結構可在電子顯微鏡下觀察到。
  • Inside the reactor the large molecules are cracked into smaller molecules. 在反應堆里,大分子裂變為小分子。
7 molecular mE9xh     
adj.分子的;克分子的
參考例句:
  • The research will provide direct insight into molecular mechanisms.這項研究將使人能夠直接地了解分子的機理。
  • For the pressure to become zero, molecular bombardment must cease.當壓強趨近于零時,分子的碰撞就停止了。
8 bind Vt8zi     
vt.捆,包扎;裝訂;約束;使凝固;vi.變硬
參考例句:
  • I will let the waiter bind up the parcel for you.我讓服務生幫你把包裹包起來。
  • He wants a shirt that does not bind him.他要一件不使他覺得過緊的襯衫。
9 resonance hBazC     
n.洪亮;共鳴;共振
參考例句:
  • Playing the piano sets up resonance in those glass ornaments.一彈鋼琴那些玻璃飾物就會產生共振。
  • The areas under the two resonance envelopes are unequal.兩個共振峰下面的面積是不相等的。
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